Autoimmune uveitis: The associated proinflammatory molecules and the search for immunoregulation

Abstract Uveitis is an intraocular inflammatory disease causing a significant visual impairment. The disease can be idiopathic, associated with infectious and systemic disorders or arisen from an unknown cause. Over the last 20 years the model of EAU in mice has contributed significantly for the est...

Full description

Saved in:
Bibliographic Details
Published in:Autoimmunity reviews 2011-02, Vol.10 (4), p.205-209
Main Authors: Commodaro, Alessandra Goncalves, Bueno, Valquiria, Belfort, Rubens, Rizzo, Luiz Vicente
Format: Article
Language:English
Subjects:
Allergy and Immunology
Autoimmune uveitis
EAU
Immune response
Immunoregulation
Inflammatory molecules
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Uveitis is an intraocular inflammatory disease causing a significant visual impairment. The disease can be idiopathic, associated with infectious and systemic disorders or arisen from an unknown cause. Over the last 20 years the model of EAU in mice has contributed significantly for the establishment of parameters for diagnostic evaluations and therapies for posterior uveitis in human. Many studies using recently discovered molecules which present proinflammatory and anti-inflammatory effects have been described. Moreover, new approaches of research provided by the increasing body of knowledge on components of immune responses such as cytokines, T-cell subpopulations and their associated functions have contributed for the further understanding of uveitis and possible treatment.
ISSN:1568-9972
1568-9972
DOI:10.1016/j.autrev.2010.10.002