The mitochondrial channel VDAC has a cation-selective open state

The mitochondrial channel VDAC is known to have two major classes of functional states, a large conductance “open” state that is anion selective, and lower conductance substates that are cation selective. The channel can reversibly switch between open and half-open states, with the latter predominan...

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Published in:Biochimica et biophysica acta 2005-12, Vol.1710 (2), p.96-102
Main Authors: Pavlov, Evgeny, Grigoriev, Sergey M., Dejean, Laurent M., Zweihorn, Chaninah L., Mannella, Carmen A., Kinnally, Kathleen W.
Format: Article
Language:English
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Summary:The mitochondrial channel VDAC is known to have two major classes of functional states, a large conductance “open” state that is anion selective, and lower conductance substates that are cation selective. The channel can reversibly switch between open and half-open states, with the latter predominant at increasing membrane voltages of either polarity. We report the presence of a new functional state of VDAC, a cation-selective state with conductance approximately equal to that of the canonical open state. This newly described state of VDAC can be reached from either the half-open cation-selective state or from the open anion-selective state. The latter transition implies that a mechanism exists for selectivity gating in VDAC that is separate from partial closure, which may be relevant to the physiological regulation of this channel and mitochondrial outer membrane permeability.
ISSN:0005-2728
0006-3002
1879-2650
DOI:10.1016/j.bbabio.2005.09.006