Autoantibody biomarkers in the detection of cancer

By definition, tumor biomarkers are selective molecules that can distinguish between patients with cancer and controls. Serum tumor markers have been the most widely used approach for cancer detection. However, the limitations of these markers, which are based on the measurement of tumor antigens, p...

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Bibliographic Details
Published in:Biochimica et biophysica acta 2006-06, Vol.1762 (6), p.587-591
Main Author: Cho-Chung, Yoon S.
Format: Article
Language:English
Subjects:
Animals
Annexins - immunology
Autoantibodies - blood
Autoantibodies - immunology
Autoantibody ECPKA
Autoantibody-based EIA
Biomarkers
Biomarkers, Tumor - blood
Biomarkers, Tumor - immunology
cAMP-dependent protein kinase
Cancer detection
Humans
Neoplasms - blood
Neoplasms - diagnosis
Neoplasms - immunology
Osteopontin
Sialoglycoproteins - blood
Tumor Suppressor Protein p53 - immunology
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Summary:By definition, tumor biomarkers are selective molecules that can distinguish between patients with cancer and controls. Serum tumor markers have been the most widely used approach for cancer detection. However, the limitations of these markers, which are based on the measurement of tumor antigens, preclude their general use in cancer screening and diagnosis. Here we give an overview of recent cancer biomarker developments based on the detection of autoantibodies produced against tumor antigens in patients' sera. This new detection method can measure the autoantibodies for a spectrum of tumor antigens in a single assay, with sensitivity and specificity exceeding those obtained using the conventional antigen determination method. Autoantibodies against serum cancer biomarkers offer a novel technology for cancer detection.
ISSN:0925-4439
0006-3002
1879-260X
DOI:10.1016/j.bbadis.2006.04.001