Altered signaling pathways linked to angiotensin II underpin the upregulation of renal Na+-ATPase in chronically undernourished rats

• Published in: Biochimica et biophysica acta 2014-12, Vol.1842 (12), p.2357-2366
• Main Authors: Silva, Paulo A., Muzi-Filho, Humberto, Pereira-Acácio, Amaury, Dias, Juliana, Martins, João F.S., Landim-Vieira, Maicon, Verdoorn, Karine S., Lara, Lucienne S., Vieira-Filho, Leucio D., Cabral, Edjair V., Paixão, Ana D.O., Vieyra, Adalberto
• Format: Article
• Language: English
• Subjects: Adenosine Triphosphatases - chemistry; Adenosine Triphosphatases - metabolism; Amino Acid Sequence; Angiotensin II - metabolism; Angiotensin II - pharmacology; Animals; Biocatalysis - drug effects; Blotting, Western; Cation Transport Proteins - chemistry; Cation Transport Proteins - metabolism; Chronic undernutrition; Cyclic AMP-Dependent Protein Kinases - metabolism; Furosemide - pharmacology; Humans; Kidney; Kidney - enzymology; Kidney Tubules, Proximal - cytology; Kidney Tubules, Proximal - metabolism; Kinetics; Male; Malnutrition - metabolism; Malnutrition - physiopathology; Models, Molecular; Molecular Sequence Data; Ouabain - pharmacology; Phosphorylation; PKA; PKC; Protein Kinase C - metabolism; Protein Structure, Tertiary; Rats, Wistar; Receptor, Angiotensin, Type 1 - metabolism; Regulatory phosphorylation sites; Signal Transduction; Sodium - metabolism; Tubulointerstitial Ang II; Up-Regulation - drug effects
• ISSN: 0925-4439; 0006-3002; 1879-260X
• DOI: 10.1016/j.bbadis.2014.09.017

This study has investigated the participation of altered signaling linked to angiotensin II (Ang II) that could be associated with increased Na+ reabsorption in renal proximal tubules during chronic undernutrition. A multideficient chow for rats (basic regional diet, BRD) was used, which mimics several human diets widely taken in developing countries. The Vmax of the ouabain-resistant Na+-ATPase resident in the basolateral membranes increased >3-fold (P