Iron availability and infection

To successfully sustain an infection, nearly all bacteria, fungi and protozoa require a continuous supply of host iron. Literature review. Mechanisms of microbial iron acquisition are determinants for the kinds of cells, tissues and hosts in which pathogens can flourish. As a corollary, hosts posses...

Full description

Saved in:
Bibliographic Details
Published in:Biochimica et biophysica acta 2009-07, Vol.1790 (7), p.600-605
Main Author: Weinberg, Eugene D.
Format: Article
Language:English
Subjects:
Animals
Bacteria - metabolism
Bacterial Infections - physiopathology
Biofilm iron
Eukaryota - metabolism
Fungi - metabolism
Iron - metabolism
Iron Chelating Agents - therapeutic use
Iron withholding defense
Lactoferrin
Mycoses - physiopathology
Siderophore
Transferrin
Virulence - physiology
Virus Diseases - physiopathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To successfully sustain an infection, nearly all bacteria, fungi and protozoa require a continuous supply of host iron. Literature review. Mechanisms of microbial iron acquisition are determinants for the kinds of cells, tissues and hosts in which pathogens can flourish. As a corollary, hosts possess an array of iron withholding devices whereby they can suppress or abort microbial invasions. Awareness of environmental and behavioral methods that can prevent iron loading plus development of pharmaceutical agents that can block microbial access to iron may help to reduce our dependence on antibiotics.
ISSN:0304-4165
0006-3002
1872-8006
DOI:10.1016/j.bbagen.2008.07.002