Regulation of myocardial triacylglycerol synthesis and metabolism

Studies showing a correlation of excess myocardial triacylglycerol stores with apoptosis, fibrosis, and contractile dysfunction indicate that dysregulation of triacylglycerol metabolism may contribute to cardiac disease. This review covers the regulation of heart triacylglycerol accumulation at the...

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Bibliographic Details
Published in:BBA - Molecular and Cell Biology of Lipids 2003-11, Vol.1634 (3), p.63-75
Main Authors: Lewin, Tal M., Coleman, Rosalind A.
Format: Article
Language:English
Subjects:
Animals
Fatty acid uptake
Fatty Acids - metabolism
Heart
Humans
Lipolysis
Lipoprotein
Lipoproteins - biosynthesis
Lipoproteins - metabolism
Myocardium - metabolism
Triacylglycerol synthesis
Triglycerides - biosynthesis
Triglycerides - metabolism
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Summary:Studies showing a correlation of excess myocardial triacylglycerol stores with apoptosis, fibrosis, and contractile dysfunction indicate that dysregulation of triacylglycerol metabolism may contribute to cardiac disease. This review covers the regulation of heart triacylglycerol accumulation at the critical control points of fatty acid uptake, enzymes of triacylglycerol synthesis, lipolysis, and lipoprotein secretion. These pathways are discussed in the context of the central role myocardial triacylglycerol plays in cardiac energy metabolism and heart disease.
ISSN:1388-1981
0006-3002
1879-2618
DOI:10.1016/j.bbalip.2003.09.006