Sphingolipid-binding proteins

Emerging information on sphingolipid metabolism and signaling is leading to a better understanding of cellular processes such as apoptosis, cancer, cell survival and aging. In this review, we discuss the involvement of sphingolipids in these processes and focus on underlying mechanisms based on sphi...

Full description

Saved in:
Bibliographic Details
Published in:Biochimica et biophysica acta 2006-08, Vol.1761 (8), p.927-946
Main Authors: Snook, C.F., Jones, J.A., Hannun, Y.A.
Format: Article
Language:English
Subjects:
Animals
Carrier Proteins - chemistry
Ceramide
Ceramide 1-phosphate
Ceramides - chemistry
CERT
Glycosphingolipid
Humans
Lipid Metabolism
Models, Biological
Models, Molecular
Molecular Structure
Protein Structure, Tertiary
Signal Transduction
Sphingolipid
Sphingolipids - chemistry
Sphingolipids - metabolism
Sphingolipids - physiology
Sphingomyelin Phosphodiesterase - chemistry
Sphingomyelinase
Sphingosine
Sphingosine 1-phosphate
Sulfoglycosphingolipids - chemistry
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Emerging information on sphingolipid metabolism and signaling is leading to a better understanding of cellular processes such as apoptosis, cancer, cell survival and aging. In this review, we discuss the involvement of sphingolipids in these processes and focus on underlying mechanisms based on sphingolipid:protein interactions. Due to the inherent difficulty of studying lipids, we discuss techniques that are useful in the elucidation of these interactions. We classify sphingolipid-binding proteins into four main classes: receptor, effector, enzyme, and transporter. Known structures of sphingolipid-binding proteins are surveyed, and sphingolipid-binding characteristics are described, acknowledging the limitations that there are presently insufficient protein:sphingolipid complexes for more definitive conclusions on this topic. Finally we summarize relevant literature to better inform the reader about sphingolipid:protein interactions.
ISSN:1388-1981
0006-3002
1879-2618
DOI:10.1016/j.bbalip.2006.06.004