Phosphatidic acid signaling regulation of Ras superfamily of small guanosine triphosphatases

Phosphatidic acid (PA) has been increasingly recognized as an important signaling lipid regulating cell growth and proliferation, membrane trafficking, and cytoskeletal reorganization. Recent studies indicate that the signaling PA generated from phospholipase D (PLD) and diacylglycerol kinase (DGK)...

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Bibliographic Details
Published in:Biochimica et biophysica acta 2009-09, Vol.1791 (9), p.850-855
Main Authors: Zhang, Yueqiang, Du, Guangwei
Format: Article
Language:English
Subjects:
Animals
Diacylglycerol kinase
Diacylglycerol Kinase - metabolism
Humans
Phosphatidic acid
Phosphatidic Acids - metabolism
Phospholipase D
Phospholipase D - metabolism
Phospholipid
rac GTP-Binding Proteins - metabolism
Ras
ras Proteins - metabolism
Signal Transduction
Small GTPase
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Summary:Phosphatidic acid (PA) has been increasingly recognized as an important signaling lipid regulating cell growth and proliferation, membrane trafficking, and cytoskeletal reorganization. Recent studies indicate that the signaling PA generated from phospholipase D (PLD) and diacylglycerol kinase (DGK) plays critical roles in regulating the activity of some members of Ras superfamily of small guanosine triphosphatases (GTPases), such as Ras, Rac and Arf. Change of PA levels regulates the activity of small GTPases by modulating membrane localization and activity of small GTPase regulatory proteins, guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). In addition, PA also targets some small GTPases to membranes by direct binding. This review summarizes the roles of PLD and DGK in regulating the activity of several Ras superfamily members and cellular processes they control. Some future directions and the implication of PA regulation of Ras small GTPases in pathology are also discussed.
ISSN:1388-1981
0006-3002
1879-2618
DOI:10.1016/j.bbalip.2009.05.013