Genetic variation of GPLD1 associates with serum GPI-PLD levels: A preliminary study

HDL is a heterogeneous mixture of lipoprotein particles varying in composition, size, and function. We and others have described a small (7.0nm), minor (0.1% of total apolipoprotein AI) particle containing apolipoprotein AI, AIV and glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) in...

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Published in:Biochimica et biophysica acta 2012-03, Vol.1821 (3), p.381-385
Main Authors: Deeg, Mark A., Xuei, Xiaoling, Eckert, George, Considine, Robert V., Li, Ying Grace, Pratt, J. Howard
Format: Article
Language:English
Subjects:
Adolescent
Adult
Apolipoprotein AI
Cohort Studies
Female
Gene Frequency
Genetic Association Studies
Glycosylphosphatidylinositol-phospholipase D
HDL
Humans
Linkage Disequilibrium
Male
Phospholipase D - blood
Phospholipase D - genetics
Polymorphism, Single Nucleotide
Sequence Analysis, DNA
Young Adult
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Summary:HDL is a heterogeneous mixture of lipoprotein particles varying in composition, size, and function. We and others have described a small (7.0nm), minor (0.1% of total apolipoprotein AI) particle containing apolipoprotein AI, AIV and glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) in humans the function of which is not entirely known. Circulating GPI-PLD levels are regulated by multiple factors including genetics. To determine if genetic variation in GPLD1 affects circulating GPI-PLD levels, we examined the relationship between 32 SNPS upstream, within, and downstream of GPLD1 and circulating GPI-PLD levels in Caucasians (n=77) and African-Americans (n=99). The genotype distribution among races differed at 13 SNPs. Nine SNPS were associated with circulating GPI-PLD levels in Caucasians but not African-Americans. These results suggest that genetic variation of GPLD1 appears to associate with circulating GPI-PLD levels. This article is part of a Special Issue entitled Advances in High Density Lipoprotein Formation and Metabolism: A Tribute to John F. Oram (1945–2010).
ISSN:1388-1981
0006-3002
1879-2618
DOI:10.1016/j.bbalip.2011.12.009