Raf kinases: Function, regulation and role in human cancer

The Ras-Raf-MAPK pathway regulates diverse physiological processes by transmitting signals from membrane based receptors to various nuclear, cytoplasmic and membrane-bound targets, coordinating a large variety of cellular responses. Function of Raf family kinases has been shown to play a role during...

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Bibliographic Details
Published in:Biochimica et biophysica acta 2007-08, Vol.1773 (8), p.1196-1212
Main Authors: Leicht, Deborah T., Balan, Vitaly, Kaplun, Alexander, Singh-Gupta, Vinita, Kaplun, Ludmila, Dobson, Melissa, Tzivion, Guri
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Apoptosis
Cancer
Cell Differentiation
Cells, Cultured
Humans
Invertebrates
MAPK
Mice
Mice, Knockout
Mice, Transgenic
Models, Biological
Molecular Sequence Data
Neoplasms - enzymology
Neoplasms - etiology
Neoplasms - genetics
Neoplasms - therapy
Oncogenes
Phosphorylation
Raf
raf Kinases - antagonists & inhibitors
raf Kinases - chemistry
raf Kinases - genetics
raf Kinases - physiology
Ras
Sequence Homology, Amino Acid
Signal Transduction
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Summary:The Ras-Raf-MAPK pathway regulates diverse physiological processes by transmitting signals from membrane based receptors to various nuclear, cytoplasmic and membrane-bound targets, coordinating a large variety of cellular responses. Function of Raf family kinases has been shown to play a role during organism development, cell cycle regulation, cell proliferation and differentiation, cell survival and apoptosis and many other cellular and physiological processes. Aberrations along the Ras-Raf-MAPK pathway play an integral role in various biological processes concerning human health and disease. Overexpression or activation of the pathway components is a common indicator in proliferative diseases such as cancer and contributes to tumor initiation, progression and metastasis. In this review, we focus on the physiological roles of Raf kinases in normal and disease conditions, specifically cancer, and the current thoughts on Raf regulation.
ISSN:0167-4889
0006-3002
1879-2596
DOI:10.1016/j.bbamcr.2007.05.001