A more serine way to die: Defining the characteristics of serine protease-mediated cell death cascades

The morphological features observed by Kerr, Wylie and Currie in 1972 define apoptosis, necrosis and autophagy. An appreciable number of alternative systems do not fall neatly under these categories, warranting a review of alternative proteolytic machinery and its contribution to cell death. This re...

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Bibliographic Details
Published in:Biochimica et biophysica acta 2007-10, Vol.1773 (10), p.1491-1499
Main Authors: O'Connell, A.R., Stenson-Cox, C.
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Apoptosis - physiology
Caspase
Cell Death - physiology
Granzymes - metabolism
High-Temperature Requirement A Serine Peptidase 2
Humans
Mitochondria
Mitochondria - metabolism
Mitochondrial Proteins - metabolism
Serine Endopeptidases - metabolism
Serine Endopeptidases - physiology
Serine protease
Signal Transduction
Urokinase-Type Plasminogen Activator - metabolism
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Summary:The morphological features observed by Kerr, Wylie and Currie in 1972 define apoptosis, necrosis and autophagy. An appreciable number of alternative systems do not fall neatly under these categories, warranting a review of alternative proteolytic machinery and its contribution to cell death. This review aims to pinpoint key molecular features of serine protease-mediated pro-apoptotic signalling. The profile created will contribute to a standard set of biochemical criteria that can serve in differentiating within cell death subtypes.
ISSN:0167-4889
0006-3002
1879-2596
DOI:10.1016/j.bbamcr.2007.08.002