Tight junctions and the regulation of gene expression

Cell adhesion is a key regulator of cell differentiation. Cell interactions with neighboring cells and the extracellular matrix regulate gene expression, cell proliferation, polarity and apoptosis. Apical cell–cell junctions participate in these processes using different types of proteins, some of t...

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Bibliographic Details
Published in:Biochimica et biophysica acta 2009-04, Vol.1788 (4), p.761-767
Main Authors: Balda, Maria S., Matter, Karl
Format: Article
Language:English
Subjects:
Adenosine Triphosphatases - physiology
Animals
Apg-2
Beta-catenin
CCAAT-Enhancer-Binding Proteins - physiology
CDK4
Cell Adhesion - physiology
Cell cycle
Cell Differentiation - physiology
Cell Proliferation
Cingulin GEF-H1
Cyclin D1
DbpA
DNA-Binding Proteins - physiology
E-cadherin
Endosomal Sorting Complexes Required for Transport
Epithelial–mesenchymal transition
erbB-2
Gene Expression Regulation
Gene methylation
Glucocorticoid
Heat-Shock Proteins - physiology
Humans
JAM
Membrane Proteins - physiology
Microfilament Proteins - physiology
Occludin Claudin
PCNA
Phosphoproteins - physiology
Ras
Signal Transduction - physiology
Slug
Snail
Symplekin RalA
TGF-beta
Tight Junctions - physiology
Transcription Factors - physiology
Up-Regulation
VE-cadherin
ZO-1
ZO-2
ZO-3
ZONAB
Zonula Occludens-1 Protein
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Summary:Cell adhesion is a key regulator of cell differentiation. Cell interactions with neighboring cells and the extracellular matrix regulate gene expression, cell proliferation, polarity and apoptosis. Apical cell–cell junctions participate in these processes using different types of proteins, some of them exhibit nuclear and junctional localization and are called NACos for Nuclear Adhesion Complexes. Tight junctions are one type of such cell–cell junctions and several signaling complexes have been identified to associate with them. In general, expression of tight junction components suppresses proliferation to allow differentiation in a coordinated manner with adherens junctions and extracellular matrix adhesion. These tight junction components have been shown to affect several signaling and transcriptional pathways, and changes in the expression of tight junction proteins are associated with several disease conditions, such as cancer. Here, we will review how tight junction proteins participate in the regulation of gene expression and cell proliferation, as well as how they are regulated themselves by different mechanisms involved in gene expression and cell differentiation.
ISSN:0005-2736
0006-3002
1879-2642
DOI:10.1016/j.bbamem.2008.11.024