Application of high pressure laser flash photolysis in studies on selected hemoprotein reactions

This article focuses on the application of high pressure laser flash photolysis for studies on selected hemoprotein reactions with the objective to establish details of the underlying reaction mechanisms. In this context, particular attention is given to the reactions of small molecules such as diox...

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Bibliographic Details
Published in:Biochimica et biophysica acta 2008-11, Vol.1784 (11), p.1481-1492
Main Authors: Brindell, Małgorzata, Stawoska, Iwona, Orzeł, Łukasz, Łabuz, Przemysław, Stochel, Grażyna, van Eldik, Rudi
Format: Article
Language:English
Subjects:
Chemistry Techniques, Analytical - methods
Electron Transport
Hemeproteins - analysis
Hemeproteins - metabolism
Hemoprotein
High pressure flash photolysis
Lasers
Models, Biological
Models, Molecular
Photolysis
Pressure
Small molecule activation
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Summary:This article focuses on the application of high pressure laser flash photolysis for studies on selected hemoprotein reactions with the objective to establish details of the underlying reaction mechanisms. In this context, particular attention is given to the reactions of small molecules such as dioxygen, carbon monoxide, and nitric oxide with selected hemoproteins (hemoglobin, myoglobin, neuroglobin and cytochrome P450 cam), as well as to photo-induced electron transfer reactions occurring in hemoproteins (particularly in various types of cytochromes). Mechanistic conclusions based on the interpretation of the obtained activation volumes are discussed in this account.
ISSN:1570-9639
0006-3002
1878-1454
DOI:10.1016/j.bbapap.2008.08.006