Unfolded protein response at the cross roads of tumourigenesis, oxygen sensing and drug resistance in clear cell renal cell carcinoma

Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer. Despite therapeutic advances, long term survival in patients diagnosed with advanced disease is low. Efforts to understand the mechanisms promoting disease progression will likely produce novel therapeutic targets. The...

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Bibliographic Details
Published in:Biochimica et biophysica acta. Reviews on cancer 2022-11, Vol.1877 (6), p.188814, Article 188814
Main Authors: Chee, Yew Hwang, Samali, Afshin, Robinson, Claire M.
Format: Article
Language:English
Subjects:
Clear cell renal cell carcinoma (ccRCC)
Tumourigenesis
Unfolded protein response (UPR)
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Summary:Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer. Despite therapeutic advances, long term survival in patients diagnosed with advanced disease is low. Efforts to understand the mechanisms promoting disease progression will likely produce novel therapeutic targets. The unfolded protein response (UPR) is activated when unfolded protein accumulates in the endoplasmic reticulum (ER) upon cellular stress. Constitutive UPR activation is a characteristic of many malignancies. We discuss the accumulating evidence that describes a role for the UPR in ccRCC. Studies focused on UPR signalling may provide compelling avenues for therapeutic intervention in the future.
ISSN:0304-419X
1879-2561
DOI:10.1016/j.bbcan.2022.188814