Indoleamine-2,3-dioxygenase mediates neurobehavioral alterations induced by an intracerebroventricular injection of amyloid-β1-42 peptide in mice

• Published in: Brain, behavior, and immunity behavior, and immunity, 2016-08, Vol.56, p.363-377
• Main Authors: Souza, Leandro Cattelan, Jesse, Cristiano R, Antunes, Michelle S, Ruff, Jossana Rodrigues, de Oliveira Espinosa, Dieniffer, Gomes, Nathalie Savedra, Donato, Franciele, Giacomeli, Renata, Boeira, Silvana Peterini
• Format: Article
• Language: English
• Subjects: Allergy and Immunology; Alzheimer’s disease; Amyloid beta-Peptides - administration & dosage; Amyloid beta-Peptides - pharmacology; Animals; Anxiety; Anxiety - chemically induced; Behavior, Animal - drug effects; Depression; Depression - chemically induced; Disease Models, Animal; Hippocampus - drug effects; Indoleamine-2,3-dyoxigenase; Indoleamine-Pyrrole 2,3,-Dioxygenase - drug effects; Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism; Inflammation - chemically induced; Injections, Intraventricular; Kynurenine - drug effects; Kynurerine; Memory; Memory Disorders - chemically induced; Mice; Nerve Growth Factors - drug effects; Neuroinflammation; Neurotrophic factor; Peptide Fragments - administration & dosage; Peptide Fragments - pharmacology; Prefrontal Cortex - drug effects; Psychiatry; Recognition (Psychology) - drug effects; Tryptophan; Tryptophan - drug effects
• ISSN: 0889-1591; 1090-2139
• DOI: 10.1016/j.bbi.2016.03.002

Highlights • Intracerebroventricular injection of Aβ1-42 induced memory and emotional disturbances. • Aβ1-42 elicits neuroinflammation and neurotrophic deficiency in brain of mice. • Aβ1-42 increased indoleamine-2,3-dioxygenase activity in brain of mice. • Aβ1-42 increased tryptophan levels and kynurerine/tryptophan ratio in brain of mice. • Indoleamine-2,3-dioxigenase mediates behavioral disturbances induced by Aβ1-42.