Maternal immune activation transgenerationally modulates maternal care and offspring depression-like behavior

Highlights • Maternal immune activation (MIA) during pregnancy impacts maternal care behavior. • Modulation of maternal care behavior in female offspring after gestational immune challenge depends on history of MIA of male mating partner. • Second generation offspring after grand-parental gestationa...

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2017-07, Vol.63, p.127-136
Main Authors: Ronovsky, Marianne, Berger, Stefanie, Zambon, Alice, Reisinger, Sonali N, Horvath, Orsolya, Pollak, Arnold, Lindtner, Claudia, Berger, Angelika, Pollak, Daniela D
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Behavior, Animal - drug effects
Behavior, Animal - physiology
Brain Diseases
Cytokines - immunology
Depression
Depression - immunology
Depressive Disorder - immunology
Disease Models, Animal
Epigenetics
Family Characteristics
Female
Gene-Environment Interaction
Glucocorticoid receptor
Hippocampus
Male
Maternal Behavior - physiology
Maternal care behavior
Maternal Exposure - adverse effects
Maternal immune activation
Mice
Mice, Inbred C57BL
Mineralocorticoid receptor
Oxytocin receptor
Poly I-C - pharmacology
Pregnancy
Prenatal Exposure Delayed Effects - immunology
Psychiatry
Transgenerational
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Summary:Highlights • Maternal immune activation (MIA) during pregnancy impacts maternal care behavior. • Modulation of maternal care behavior in female offspring after gestational immune challenge depends on history of MIA of male mating partner. • Second generation offspring after grand-parental gestational immune challenge display augmented depression-like behavior. • Transcriptional changes in the hippocampus of first and second generation offspring with history of MIA are both, conserved and modified, across generations.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2016.10.016