GPER activation is effective in protecting against inflammation-induced nigral dopaminergic loss and motor function impairment

Highlights • GPER selective activation reduces microglial reactivity induced by LPS in vitro and in vivo. • GPER selective activation protects nigral DA neurons from the lesion induced by intranigral injection of LPS. • GPER selective activation provides functional protection against LPS-induced mot...

Full description

Saved in:
Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2017-08, Vol.64, p.296-307
Main Authors: Mendes-Oliveira, Julieta, Lopes Campos, Filipa, Alexandra Videira, Rita, Baltazar, Graça
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Cell Line
Dopaminergic neurons
Dopaminergic Neurons - metabolism
Dopaminergic Neurons - pathology
Encephalitis - chemically induced
Encephalitis - complications
Encephalitis - metabolism
GPER
Lipopolysaccharides - administration & dosage
Male
Mice, Inbred C57BL
Microglia
Microglia - metabolism
Microglia - physiology
Motor Activity
Neuroinflammation
Neuroprotection
Parkinson Disease, Secondary - metabolism
Parkinson’s disease
Phagocytosis
Psychiatry
Rats, Wistar
Receptors, Estrogen - metabolism
Receptors, G-Protein-Coupled - agonists
Receptors, G-Protein-Coupled - metabolism
Substantia Nigra - metabolism
Substantia Nigra - pathology
Tyrosine 3-Monooxygenase - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • GPER selective activation reduces microglial reactivity induced by LPS in vitro and in vivo. • GPER selective activation protects nigral DA neurons from the lesion induced by intranigral injection of LPS. • GPER selective activation provides functional protection against LPS-induced motor impairments.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2017.04.016