Effect of Early Recognition of Malnutrition and Targeted Nutrition Support on Clinical Outcomes in Autologous Stem Cell Transplant Patients

• Published in: Biology of blood and marrow transplantation 2019-03, Vol.25 (3), p.S140-S141
• Main Authors: Lazarow, Heather, Singer, Ryan, Compher, Charlene, Gilmar, Cheryl, Landsburg, Daniel J.
• Format: Article
• Language: English
• ISSN: 1083-8791; 1523-6536
• DOI: 10.1016/j.bbmt.2018.12.430

Patients (pts) admitted to hospital for autologous stem cell transplant (ASCT) are at risk for malnutrition. American Society for Parenteral and Enteral Nutrition (ASPEN) clinical guidelines recommend nutrition screening and targeted nutrition support for ASCT pts. However, these recommendations are not always followed due to lack of clear evidence of benefit and concern that nutrition support may be associated with increased risk of infection or delayed time to platelet engraftment. We evaluated clinical outcomes in consecutive ASCT pts receiving nutrition assessment and targeted nutrition support based on malnutrition status. A historical control group included consecutive pts admitted for ASCT January 2016 to October 2017 (n = 308). Beginning in October 2017, all ASCT pts (n = 148) received nutrition assessment and intervention to optimize oral intake and were included in the intervention group. Pts diagnosed with malnutrition using Academy of Nutrition and Dietetics-ASPEN criteria and continuing with 15 days after transplant. Pt characteristics included age, Karnofsky performance status (KPS), first vs. subsequent ASCT, and malnutrition risk indicated by a score ≥2 on the validated Malnutrition Screening Tool (MST). Mann-Whitney U tests comparing patients vs. historical controls and logistic regressions were conducted using SPSS (version 25), with p