Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress

We have recently showed that molecular hydrogen has great potential for selectively reducing cytotoxic reactive oxygen species, such as hydroxyl radicals, and that inhalation of hydrogen gas decreases cerebral infarction volume by reducing oxidative stress [I. Ohsawa, M. Ishikawa, K. Takahashi, M. W...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2007-09, Vol.361 (3), p.670-674
Main Authors: Fukuda, Kei-ichi, Asoh, Sadamitsu, Ishikawa, Masahiro, Yamamoto, Yasuhiro, Ohsawa, Ikuroh, Ohta, Shigeo
Format: Article
Language:English
Subjects:
Administration, Inhalation
ALT
Animals
Anti-oxidant
Hydrogen - administration & dosage
Hydrogen - therapeutic use
Hydrogen gas
Hydroxyl radical
Ischemia
Liver
Liver - blood supply
Liver - metabolism
Liver - pathology
Male
MDA
Mice
Oxidation-Reduction
Oxidative stress
Oxidative Stress - physiology
Reperfusion
Reperfusion Injury - drug therapy
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Summary:We have recently showed that molecular hydrogen has great potential for selectively reducing cytotoxic reactive oxygen species, such as hydroxyl radicals, and that inhalation of hydrogen gas decreases cerebral infarction volume by reducing oxidative stress [I. Ohsawa, M. Ishikawa, K. Takahashi, M. Watanabe, K. Nishimaki, K. Yamagata, K.-I. Katsura, Y. Katayama, S. Asoh, S. Ohta, Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals, Nat. Med., 13 (2007) 688–694]. Here we show that the inhalation of hydrogen gas is applicable for hepatic injury caused by ischemia/reperfusion, using mice. The portal triad to the left lobe and the left middle lobe of the liver were completely occluded for 90 min, followed by reperfusion for 180 min. Inhalation of hydrogen gas (1–4%) during the last 190 min suppressed hepatic cell death, and reduced levels of serum alanine aminotransferase and hepatic malondialdehyde. In contrast, helium gas showed no protective effect, suggesting that the protective effect by hydrogen gas is specific. Thus, we propose that inhalation of hydrogen gas is a widely applicable method to reduce oxidative stress.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2007.07.088