The PGC-1α-dependent pathway of mitochondrial biogenesis is upregulated in type I endometrial cancer

PGC-1α-dependent pathway of mitochondrial biogenesis was investigated for the first time in type I endometrial cancer and in normal endometrium. In cancer endometrial tissue the citrate synthase activity, the mitochondrial DNA content and the TFAM level were found doubled compared to control endomet...

Full description

Saved in:
Bibliographic Details
Published in:Biochemical and biophysical research communications 2009-12, Vol.390 (4), p.1182-1185
Main Authors: Cormio, Antonella, Guerra, Flora, Cormio, Gennaro, Pesce, Vito, Fracasso, Flavio, Loizzi, Vera, Cantatore, Palmiro, Selvaggi, Luigi, Gadaleta, Maria Nicola
Format: Article
Language:English
Subjects:
Mitochondrial biogenesis
mtDNA content
NRF-1
PGC-1α
TFAM
Type I endometrial cancer
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:PGC-1α-dependent pathway of mitochondrial biogenesis was investigated for the first time in type I endometrial cancer and in normal endometrium. In cancer endometrial tissue the citrate synthase activity, the mitochondrial DNA content and the TFAM level were found doubled compared to control endometrial tissue. Moreover, a 1.6- and 1.8-fold increase, respectively, of NRF-1 and PGG-1α expression was found. This study demonstrates, for the first time, that the increased mitochondrial biogenesis in type I endometrial cancer is associated to the upregulation of PGC-1α signalling pathway.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2009.10.114