Applications for nitric oxide in halting proliferation of tumor cells

► We discuss the role of nitric oxide in cancer. ► We discuss the potential for nitric oxide donors as anticancer therapeutics. ► We present examples of nitric oxide donating pro-drugs. Tumor resistance to cytotoxic therapeutics coupled with dose-limiting toxicity is a serious hurdle in the field of...

Full description

Saved in:
Bibliographic Details
Published in:Biochemical and biophysical research communications 2013-02, Vol.431 (4), p.647-651
Main Authors: Reynolds, Melissa M., Witzeling, Scott D., Damodaran, Vinod B., Medeiros, Tysha N., Knodle, Ryan D., Edwards, Melissa A., Lookian, Pashayar P., Brown, Mark A.
Format: Article
Language:English
Subjects:
Adjuvant therapy
Apoptosis - drug effects
Cancer therapy
Cell Proliferation - drug effects
Cell signaling
Drug Resistance, Neoplasm
Humans
Neoplasms - drug therapy
Neoplasms - metabolism
Nitric oxide
Nitric Oxide - metabolism
Nitric Oxide Donors - pharmacology
Nitric Oxide Donors - therapeutic use
Pro-drugs
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:► We discuss the role of nitric oxide in cancer. ► We discuss the potential for nitric oxide donors as anticancer therapeutics. ► We present examples of nitric oxide donating pro-drugs. Tumor resistance to cytotoxic therapeutics coupled with dose-limiting toxicity is a serious hurdle in the field of medical oncology. In the face of this obstacle, nitric oxide has emerged as a powerful adjuvant for the hypersensitization of tumors to more traditional chemo- and radio-therapeutics. Furthermore, emerging evidence indicates that nitric oxide donors have the potential to function independently in the clinical management of cancer. Herein, we discuss the role of nitric oxide in cancer and the potential for nitric oxide donors to support conventional therapeutics.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2013.01.041