Current perspectives of molecular pathways involved in chronic inflammation-mediated breast cancer

• Published in: Biochemical and biophysical research communications 2016-04, Vol.472 (3), p.401-409
• Main Authors: Suman, Shankar, Sharma, Pradeep Kumar, Rai, Girish, Mishra, Sanjay, Arora, Deepika, Gupta, Prachi, Shukla, Yogeshwer
• Format: Article
• Language: English
• Subjects: angiogenesis; Animals; autophagy; Breast cancer; breast neoplasms; Breast Neoplasms - etiology; Breast Neoplasms - immunology; Cancer progression; carcinogenesis; Carcinogenesis - immunology; chemokines; Chronic Disease; Chronic inflammation; clones; Cytokines - immunology; drug resistance; Female; growth factors; Humans; Immune cells; immune response; Immunity, Innate - immunology; Immunologic Factors - immunology; immunomodulation; inflammation; Mastitis - complications; Mastitis - immunology; mitogen-activated protein kinase; Models, Immunological; oxidative stress; signal transduction; Signal Transduction - immunology; Signaling pathways; stem cells; transcription factor NF-kappa B
• ISSN: 0006-291X; 1090-2104
• DOI: 10.1016/j.bbrc.2015.10.133

Inflammation has multifaceted role in cancer progression including initiation, promotion and invasion by affecting the immune surveillance and associated signaling pathways. Inflammation facilitates the over-expression of cytokines, chemokines and growth factors involved in progression of different cancers including breast cancer progression. Deregulation of biological processes such as oxidative stress, angiogenesis, and autophagy elicit favorable immune response towards chronic inflammation. Apart from the role in carcinogenesis, chronic inflammation also favors the emergence of drug resistance clones by inducing the growth of breast cancer stem-like cells. Immunomodulation mediated by cytokines, chemokines and several other growth factors present in the tumor microenvironment regulate chronic inflammatory response and alter crosstalk among various signaling pathways such as NF-κB, Nrf-2, JAK-STAT, Akt and MAPKs involved in the progression of breast cancer. In this review, we focused on cellular and molecular processes involved in chronic inflammation, crosstalk among different signaling pathways and their association in breast cancer pathogenesis. •Overview of chronic inflammation in carcinogenesis.•Deregulated biological process and immune response is key factor of chronic inflammation.•Various signaling pathways governed in chronic inflammation mediate breast cancer pathogenesis.•Delineating complexity in chronic inflammation may directly link to therapeutic interventions of breast cancer.