Reproductive toxicity provoked by titanium dioxide nanoparticles and the ameliorative role of Tiron in adult male rats

Titanium dioxide nanoparticles (TDN) are widely used in paints, plastics, ceramics, cosmetics, printing ink, rubber and paper. Tiron is a water soluble metal chelator and antioxidant. This study was designed to investigate the reproductive toxicity of TDN in male albino rats and the ameliorative rol...

Full description

Saved in:
Bibliographic Details
Published in:Biochemical and biophysical research communications 2017-04, Vol.486 (2), p.595-600
Main Authors: Morgan, Ashraf M., Ibrahim, Marwa A., Noshy, Peter A.
Format: Article
Language:English
Subjects:
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt - pharmacology
Animals
Antioxidants - pharmacology
Drug Administration Schedule
Gene Expression
Injections, Intraperitoneal
Male
Micronuclei, Chromosome-Defective
Nanoparticles - toxicity
Oxidative Stress
Proteins - agonists
Proteins - genetics
Proteins - metabolism
Rats
Reproduction - drug effects
Reproduction - genetics
Reproductive toxicity
Semen Analysis
Sperm Count
Sperm Motility - drug effects
TDN
Testis - drug effects
Testis - metabolism
Testis - pathology
Tiron
Titanium - toxicity
Titanium dioxide nanoparticles
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Titanium dioxide nanoparticles (TDN) are widely used in paints, plastics, ceramics, cosmetics, printing ink, rubber and paper. Tiron is a water soluble metal chelator and antioxidant. This study was designed to investigate the reproductive toxicity of TDN in male albino rats and the ameliorative role of Tiron to minimize such toxic effects. Eighty adult male albino rats were assigned into 4 equal groups, group 1: control; group 2: received TDN at 100 mg/kg/day orally for 8 weeks; group 3: received Tiron at 470 mg/kg/day intraperitoneally for 2 weeks (the last 2 weeks of the experimental period); group 4: received both TDN and Tiron by the same previously mentioned dose, route and duration. The results revealed that TDN provoked reproductive toxicity which was proved by the deteriorated spermogram picture, high incidence of micronucleated RBCs, elevated oxidative stress parameters and up regulation of Testin gene. Whereas, Tiron co-treatment ameliorated most of these toxic alterations. Our findings highlighted the protective role of tiron against TDN intoxication.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2017.03.098