Effects of curcumin and ursolic acid on the mitochondrial coupling efficiency and hydrogen peroxide emission of intact skeletal myoblasts

Curcumin may improve blood glucose management, but the mechanism is not fully established. We demonstrated that curcumin (40 μM) reduced the mitochondrial coupling efficiency (percentage of oxygen consumption coupled to ATP synthesis) of intact skeletal muscle cells. A 30-minute pretreatment with cu...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2017-10, Vol.492 (3), p.368-372
Main Authors: Tueller, Daniel J., Harley, Jackson S., Hancock, Chad R.
Format: Article
Language:English
Subjects:
Animals
Cells, Cultured
Curcumin
Curcumin - pharmacology
Hydrogen peroxide
Hydrogen Peroxide - metabolism
Mice
Mitochondria
Mitochondria - drug effects
Mitochondria - metabolism
Myoblasts, Skeletal - drug effects
Myoblasts, Skeletal - metabolism
Oxygen consumption
Skeletal muscle
Triterpenes - pharmacology
Ursolic Acid
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Summary:Curcumin may improve blood glucose management, but the mechanism is not fully established. We demonstrated that curcumin (40 μM) reduced the mitochondrial coupling efficiency (percentage of oxygen consumption coupled to ATP synthesis) of intact skeletal muscle cells. A 30-minute pretreatment with curcumin reduced mitochondrial coupling efficiency by 17.0 ± 0.4% relative to vehicle (p 
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2017.08.101