Pectolinarigenin, an aglycone of pectolinarin, has more potent inhibitory activities on melanogenesis than pectolinarin

Pectolinarin and pectolinarigenin have been reported to be major compounds in Cirsium setidens. In the present study, we demonstrated inhibitory effects of pectolinarin and pectolinarigenin from C. setidens on melanogenesis. Melanin synthesis was decreased in both pectolinarin- and pectolinarigenin-...

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Published in:Biochemical and biophysical research communications 2017-11, Vol.493 (1), p.765-772
Main Authors: Lee, Sullim, Lee, Da-Hye, Kim, Jin-Chul, Um, Byung Hun, Sung, Sang Hyun, Jeong, Lak Shin, Kim, Yong Kee, Kim, Su-Nam
Format: Article
Language:English
Subjects:
Cells, Cultured
Chromones - administration & dosage
Cirsium - chemistry
Cirsium setidens
Dose-Response Relationship, Drug
Humans
Iridoids - administration & dosage
Melanins - biosynthesis
Melanogenesis
Microwave
Pectolinarigenin
Pectolinarin
Plant Extracts - administration & dosage
Skin - cytology
Skin - drug effects
Skin - metabolism
Whitening
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Summary:Pectolinarin and pectolinarigenin have been reported to be major compounds in Cirsium setidens. In the present study, we demonstrated inhibitory effects of pectolinarin and pectolinarigenin from C. setidens on melanogenesis. Melanin synthesis was decreased in both pectolinarin- and pectolinarigenin-treated melan-a cells and in a reconstructed human skin model. However, pectolinarigenin treatment showed more potent inhibitory activity of melanin synthesis than did pectolinarin treatment. The concentrations of pectolinarin and pectolinarigenin in C. setidens water extracts were determined by HPLC. Unfortunately, the amount of pectolinarigenin of C. setidens water extract was lower than that of pectolinarin. To increase the pectolinarigenin content in C. setidens water extract, several component conversion methods were studied. Consequently, we identified that microwave irradiation under 1% acetic acid was an optimum sugar elimination method. [Display omitted] •Pectolinarigenin has more potent inhibitory effects than pectolinarin on melanin synthesis in melan-a cells.•Pectolinarigenin has more potent inhibitory effects than pectolinarin on expression of melanogenesis-related genes.•Pectolinarigenin has inhibitory effect on melanin production in a reconstructed human skin model.•Microwave irradiation under 1% acetic acid conditions is optimal to convert pectolinarin into pectolinarigenin.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2017.08.106