In vitro and in vivo antitumor activity of deoxyelephantopin from a potential medicinal plant Elephantopus scaber against Ehrlich ascites carcinoma

Elephantopus scaber Linn. is a perennial medicinal herb widely used in Asian traditional medicine for the treatment of different kinds of neoplasm. The aim of the present study was to appraise the in vitro and in vivo antitumor activity of deoxyelephantopin (DOE) - the active principle isolated from...

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Bibliographic Details
Published in:Biocatalysis and agricultural biotechnology 2019-05, Vol.19, p.101106, Article 101106
Main Authors: Kabeer, Farha Arakkaveettil, Rajalekshmi, Dhanya Sethumadhavan, Nair, Mangalam Sivasankaran, Prathapan, Remani
Format: Article
Language:English
Subjects:
Apoptosis
Deoxyelephantopin
Ehrlich ascites carcinoma (EAC)
Elephantopus scaber
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Summary:Elephantopus scaber Linn. is a perennial medicinal herb widely used in Asian traditional medicine for the treatment of different kinds of neoplasm. The aim of the present study was to appraise the in vitro and in vivo antitumor activity of deoxyelephantopin (DOE) - the active principle isolated from E. scaber against murine Ehrlich ascites carcinoma (EAC). Intraperitoneal administration of DOE (25 mg/kg) reduced the ascites tumor volume to a better extend than the treatments with same concentrations of 5-Flourouracil (5-FU) in EAC ascites tumor model and increased the life span of treated mice with respect to control mice (p ˂ 0.001). Moreover, treatment with 25 mg/kg DOE reduced the tumor volume and tumor burden in EAC solid tumor model and showed the best overall survival responses (Log-Rank p value 
ISSN:1878-8181
1878-8181
DOI:10.1016/j.bcab.2019.101106