An investigation on antidiabetic competence of Ferula assafoetida mediated AgNPs on diabetic (STZ) induced albino rats

• Published in: Biocatalysis and agricultural biotechnology 2024-02, Vol.56, p.103043, Article 103043
• Main Authors: Subramaniam, Saranyadevi, Roy, Anitha, Vivekanandan, K.E., Ahamed, A. Asrar, Bharathiraja, C., Kumarasamy, Suresh, Raja, Rathinam, S.AlSalhi, Mohamad, Narayanan, Mathiyazhagan
• Format: Article
• Language: English
• Subjects: Antidiabetic activity; Antihyperlipidemic histopathology; F. assafoetida resin; Glibenclamide
• ISSN: 1878-8181; 1878-8181
• DOI: 10.1016/j.bcab.2024.103043

Ferula resin is a versatile and promising plant material, particularly for anti-diabetic purposes. In this study, the resin was extracted and biologically synthesized through silver nanoparticles, which was characterized using UV–Vis spectra at 485 nm, formation of the spherical shaped AgNPs1 size range of 35–40 nm showed clear dispersion with less aggregation in TEM analysis and proved by EDAX, XRD, and DLS. The acute toxicity level of raw ethanolic extracts of asafoetida and silver synthesized nanoparticles against albino Wister rats were showed less toxicity effective concentration of AgNPs (NPs1) at 150 mg/kg as well as raw ethanolic extracts at 200 mg/kg BW and were found to be significant. Hence, the study found a significant decrease in the blood glucose levels after 28 days of treatment on six groups of albino rats, when compared to diabetic control. The ethanolic extract (Ferula resin) considerably reduced blood glucose levels from 388.67 ± 3.2 to 365.14 ± 2.2 mg/dL, while the synthesized AgNPs treatment significantly reduced the glucose level from 528.12 ± 42.7 to 315.2 ± 61.81 mg/dL. When compared to control rats, diabetic controls had significantly higher levels of total cholesterol, triglycerides, low density lipoprotein, high density lipoprotein, and very low density lipoprotein throughout the study. Histopathological analyses demonstrated the importance of retrieval in kidneys and pancreas treated with AgNPs and then treated with raw ethanolic extracts. Finally, this study has the potential to improve the efficacy and convenience of diabetes treatment alternatives over previously indicated anti diabetic medicines.