Coix polysaccharides: Gut microbiota regulation and immunomodulatory

Coix (Coix lachryma-jobi L.), commonly known as adlay or Job's tears, is a minor cereal grown in most areas of Asia. It has been used in the traditional Chinese medicine for thousands of years, used as a stomachic, diuretic, analgesic, antispasmodic, and anti-inflammatory agent. It contains a r...

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Bibliographic Details
Published in:Bioactive carbohydrates and dietary fibre 2018-10, Vol.16, p.53-61
Main Authors: Yin, Hong-Mei, Wang, Su-Nan, Nie, Shao-Ping, Xie, Ming-Yong
Format: Article
Language:English
Subjects:
Coix seed
Gut microbiota
Immunomodulatory
Polysaccharides
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Summary:Coix (Coix lachryma-jobi L.), commonly known as adlay or Job's tears, is a minor cereal grown in most areas of Asia. It has been used in the traditional Chinese medicine for thousands of years, used as a stomachic, diuretic, analgesic, antispasmodic, and anti-inflammatory agent. It contains a range of bioactive components including polysaccharides, lipids, polyphenols, phytosterols, carotenoids, spiroenone and lactams. The bioactive constituents contributed to some health benefits include anti-oxidation, anti-cancer, anti-inflammation, anti-allergy, enhancing immunological activity, regulating endocrine functions, anti-obesity, anti-diabetes, gastroprotection, hypolipidemia, and modulating gut microbiota. Polysaccharides have aroused more and more interest from researchers, because the potential of prebiotic and immunity activity. Coix polysaccharides showed anti-oxidative, anti-cancer, gut microbiota modification, hypoglycemic, anti-complementary and immunological modulation activities. In this review, we summarized in detail the current knowledge on the cross-talk mechanisms that mediate polysaccharides, intestinal microbiota, and immune system interactions, as well as the effects of coix polysaccharides on the gut bacteria and immunomodulatory properties. [Display omitted] •This review firstly summarized structures and health effects of coix polysaccharides.•Coix polysaccharides have the potential of gut microbiota regulation and immunomodulatory.•This review summarized in detail the current knowledge on the cross-talk mechanisms that mediate polysaccharides, intestinal microbiota, and immune system interactions.
ISSN:2212-6198
2212-6198
DOI:10.1016/j.bcdf.2018.04.002