Cell-specific drug targeting in the lung

[Display omitted] Non-targeted drug delivery systems have several limitations including the decreased bioavailability of the drug, poor stability and rapid clearance in addition to off-target distribution. Cell-specific targeted delivery approaches promise to overcome some of these limitations and e...

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Bibliographic Details
Published in:Biochemical pharmacology 2021-08, Vol.190, p.114577, Article 114577
Main Authors: Abed, Soumeya, Turner, Rebecca, Serniuck, Nickolas, Tat, Victor, Naiel, Safaa, Hayat, Aaron, Mekhael, Olivia, Vierhout, Megan, Ask, Kjetil, Rullo, Anthony F.
Format: Article
Language:English
Subjects:
Biopolymers
Cell-specific
Drug release
Drug targeting
Immunotherapy
Lung
Nanocarriers
Pharmacokinetics
Site activated drugs
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Summary:[Display omitted] Non-targeted drug delivery systems have several limitations including the decreased bioavailability of the drug, poor stability and rapid clearance in addition to off-target distribution. Cell-specific targeted delivery approaches promise to overcome some of these limitations and enhance therapeutic selectivity. In this review, we aim to discuss cell-specific targeted approachesin the lung at the biochemical and molecular levels. These approaches include;a) directly administered small molecule drugs with intracellular action; b) targeted biologics and synthetic hybrids with extracellular action; c) site activateddrugs; and d) delivery systems.We discuss the pharmaceutical and biochemical parameters that govern the fate of drug molecules at delivery sites while presenting an overview of relevant literature surrounding this area of research and current advancements.
ISSN:0006-2952
1873-2968
DOI:10.1016/j.bcp.2021.114577