Ethnic differences in the clinical presentation of Graves’ ophthalmopathy

Ethnic differences in a number of eye conditions have been described. The literature on ethnic differences in Graves’ ophthalmopathy (GO) is limited. There is some evidence to suggest Asian patients with GO may manifest milder phenotypic features of GO, with less proptosis and evidence of extraocula...

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Bibliographic Details
Published in:Baillière's best practice & research. Clinical endocrinology & metabolism 2012-06, Vol.26 (3), p.249-258
Main Authors: Chng, Chiaw-Ling, MBBS, MRCP, Seah, Lay Leng, MBBS, FRCS(Ed), FRCOphth, FAMS, Khoo, Daphne Hsu Chin, MBBS, MMed (Int Med), FAMS, FRCP
Format: Article
Language:English
Subjects:
Endocrinology & Metabolism
ethnicity
Graves’ disease
Graves’ ophthalmopathy
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Summary:Ethnic differences in a number of eye conditions have been described. The literature on ethnic differences in Graves’ ophthalmopathy (GO) is limited. There is some evidence to suggest Asian patients with GO may manifest milder phenotypic features of GO, with less proptosis and evidence of extraocular muscle involvement and restriction. The reasons for these differences are likely to be multifactorial and include orbital and lid anatomy, genetic background and autoimmune responses including TSH –receptor antibodies. These differences should be kept in mind when evaluating and managing patients with GO.
ISSN:1521-690X
1878-1594
DOI:10.1016/j.beem.2011.10.004