Bilirubin and tryptophan adsorption in albumin-containing solutions

Albumin-bound toxins are involved in the aetiology of many liver failure associated pathologies and specific processes aimed to their removal have been developed. In general, adsorption plays an important role in all of these processes. In this paper, two albumin-bound toxins (bilirubin and tryptoph...

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Bibliographic Details
Published in:Biochemical engineering journal 2008-06, Vol.40 (2), p.205-210
Main Authors: Annesini, Maria Cristina, Di Carlo, Chiara, Piemonte, Vincenzo, Turchetti, Luca
Format: Article
Language:English
Subjects:
Adsorption
Amino acid
Artificial liver
Bilirubin
Modelling
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Summary:Albumin-bound toxins are involved in the aetiology of many liver failure associated pathologies and specific processes aimed to their removal have been developed. In general, adsorption plays an important role in all of these processes. In this paper, two albumin-bound toxins (bilirubin and tryptophan) were considered and their adsorption equilibrium on activated carbon in albumin-containing solutions was investigated. The experimental results clearly show that the higher the albumin concentration in the liquid phase, the lower the toxin adsorbed amount. This effect was quantitatively analysed by means of a mathematical model that accounts for chemical and non-chemical interactions between albumin and toxin adsorption.
ISSN:1369-703X
1873-295X
DOI:10.1016/j.bej.2007.12.010