Linear robust control of S. cerevisiae fed-batch cultures at different scales

In this paper, experimental investigations of an adaptive RST control scheme for the regulation of the ethanol concentration in fed-batch cultures of S. cerevisiae is presented. Our main objective is to prove efficiency and robustness of this controller in experimental applications ranging from labo...

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Bibliographic Details
Published in:Biochemical engineering journal 2010-12, Vol.53 (1), p.26-37
Main Authors: Dewasme, L., Richelle, A., Dehottay, P., Georges, P., Remy, M., Bogaerts, Ph, Vande Wouwer, A.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Bioreactor systems
Bioreactors
Biotechnology
Control systems & optimization
Fundamental and applied biological sciences. Psychology
Metabolic control
Methods. Procedures. Technologies
On-line fed-batch
Recombinant technology
Stirred tank
Various methods and equipments
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Summary:In this paper, experimental investigations of an adaptive RST control scheme for the regulation of the ethanol concentration in fed-batch cultures of S. cerevisiae is presented. Our main objective is to prove efficiency and robustness of this controller in experimental applications ranging from laboratory to industrial scales. The controller only requires one on-line measurement signal, making it easily implementable in an industrial environment. Disturbance rejection is ensured thanks to an on-line parameter adaptation procedure, which delivers as a side product an estimate of the growth rate that can be used for process monitoring purposes. The robustification of the controller is achieved in a simple way, using the observer polynomial.
ISSN:1369-703X
1873-295X
DOI:10.1016/j.bej.2009.10.001