Emerging role of protein kinase B/Akt signaling in pancreatic β-cell mass and function

The serine-threonine kinase Akt also known as protein kinase B is one of the most studied molecules. In addition to the important role in carcinogenesis, Akt is a major regulator of carbohydrate metabolism. Akt mediates insulin-dependent glucose uptake in insulin-sensitive tissues. Recent evidence u...

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Bibliographic Details
Published in:The international journal of biochemistry & cell biology 2006-01, Vol.38 (5), p.689-695
Main Authors: Elghazi, Lynda, Balcazar, Norman, Bernal-Mizrachi, Ernesto
Format: Article
Language:English
Subjects:
Akt
Islets
PKB
β-Cell mass
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Summary:The serine-threonine kinase Akt also known as protein kinase B is one of the most studied molecules. In addition to the important role in carcinogenesis, Akt is a major regulator of carbohydrate metabolism. Akt mediates insulin-dependent glucose uptake in insulin-sensitive tissues. Recent evidence underscores the importance of Akt for regulation of β-cell mass and function. This review summarizes current findings concerning the molecular mechanisms, downstream signaling pathways, and critical components involved in regulation of β-cell mass and function by Akt. The results of these observations suggest that elucidation of critical downstream effectors of this signaling pathway could generate promising molecules as a potential target to induce proliferation and survival of β-cells.
ISSN:1357-2725
1878-5875
DOI:10.1016/j.biocel.2006.01.005