A panel of circulating long non-coding RNAs as liquid biopsy biomarkers for breast and cervical cancers

The early detection and diagnosis of cancer is critical to optimize the treatment and management of cancer patients. Typical methods such as imaging and tissue biopsy are invasive, time-consuming, and often imprecise. Thus, recent technological advances of dependable, facile, and minimally invasive...

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Bibliographic Details
Published in:Biochimie 2020-09, Vol.176, p.62-70
Main Authors: Barwal, Tushar Singh, Sharma, Uttam, Vasquez, Karen M., Prakash, Hridayesh, Jain, Aklank
Format: Article
Language:English
Subjects:
Biomarkers
Biomarkers, Tumor - blood
Breast cancer
Breast Neoplasms - blood
Cell-Free Nucleic Acids - blood
Cervical cancer
Circulating lncRNA
Female
Humans
Liquid Biopsy
lncRNA signature
Prognosis
RNA, Long Noncoding - blood
RNA, Neoplasm - blood
Uterine Cervical Neoplasms - blood
Uterine Cervical Neoplasms - pathology
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Summary:The early detection and diagnosis of cancer is critical to optimize the treatment and management of cancer patients. Typical methods such as imaging and tissue biopsy are invasive, time-consuming, and often imprecise. Thus, recent technological advances of dependable, facile, and minimally invasive collectible oncogenic biomarkers using human biofluids and secretions have been an active area of research. Recently, circulating long non-coding RNAs (lncRNAs) have been identified as promising biomarkers that fulfill many recommended properties of successful biomarkers for cancer diagnosis and prognosis. LncRNAs play essential roles in many cellular processes including DNA repair, cell proliferation, and epithelial-to-mesenchymal transition (EMT) by regulating the expression of various genes associated with cancer development and progression. Herein, we discuss the regulatory functions/pathways associated with multiple cancer-associated lncRNAs and their potential as prognostic/diagnostic markers for breast and cervical cancers. Additionally, we provide a correlation between lncRNA levels in the blood and clinicopathological data, including sensitivity, specificity, and Area Under Curve (AUC) merits of model performance value. [Display omitted] •A Panel of circulating lncRNAs involved in tumorigenesis and development of breast and cervical cancer.•Circulating lncRNAs regulate various signaling pathways involved in breast and cervical cancer.•The levels of circulating lncRNAs may provide novel diagnostic and/or prognostic biomarkers for breast and cervical cancer.•Circulating lncRNAs may be used as therapeutic targets for breast and cervical cancers.
ISSN:0300-9084
1638-6183
DOI:10.1016/j.biochi.2020.06.012