E-jet 3D printed drug delivery implants to inhibit growth and metastasis of orthotopic breast cancer

Drug-loaded implants have attracted considerable attention in cancer treatment due to their precise delivery of drugs into cancer tissues. Contrary to injected drug delivery, the application of drug-loaded implants remains underutilized given the requirement for a surgical operation. Nevertheless, d...

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Bibliographic Details
Published in:Biomaterials 2020-02, Vol.230, p.119618, Article 119618
Main Authors: Yang, Yikun, Qiao, Xiaoyin, Huang, Ruiying, Chen, Haoxiang, Shi, Xuelei, Wang, Jian, Tan, Weihong, Tan, Zhikai
Format: Article
Language:English
Subjects:
3D printing
Breast Neoplasms - drug therapy
Breast tumor
Combination chemotherapy
Controlled release
Drug delivery
Drug Delivery Systems
Drug Implants - therapeutic use
Fluorouracil - therapeutic use
Humans
Pharmaceutical Preparations
Printing, Three-Dimensional
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Summary:Drug-loaded implants have attracted considerable attention in cancer treatment due to their precise delivery of drugs into cancer tissues. Contrary to injected drug delivery, the application of drug-loaded implants remains underutilized given the requirement for a surgical operation. Nevertheless, drug-loaded implants have several advantages, including a reduction in frequency of drug administration, minimal systemic toxicity, and increased delivery efficacy. Herein, we developed a new, precise, drug delivery device for orthotopic breast cancer therapy able to suppress breast tumor growth and reduce pulmonary metastasis using combination chemotherapy. Poly-lactic-co-glycolic acid scaffolds were fabricated by 3D printing to immobilize 5-fluorouracil and NVP-BEZ235. The implantable scaffolds significantly reduced the required drug dosages and ensured curative drug levels near tumor sites for prolonged period, while drug exposure to normal tissues was minimized. Moreover, long-term drug release was achieved, potentially allowing one-off implantation and, thus, a major reduction in the frequency of drug administration. This drug-loaded scaffold has great potential in anti-tumor treatment, possibly paving the way for precise, effective, and harmless cancer therapy. Schematic illustrations of three-dimensional drug-loaded scaffolds for orthotopic breast tumor mouse treatment model. [Display omitted]
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2019.119618