Anti-HSV-1 and antioxidant activities of dicaffeoyl and digalloyl esters of quinic acid

Nine caffeic and gallic acids derivatives were synthesized and evaluated for their antioxidant activity using the DPPH radical scavenging activity assay and for their antiherpes activity against HSV-1. All compounds displayed higher antioxidant activities than α-tocopherol. The most active antioxida...

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Bibliographic Details
Published in:Biomedicine & preventive nutrition 2014-01, Vol.4 (1), p.35-38
Main Authors: Rezende, Celso O., Rigotto, Caroline, Caneschi, Wiliam, Rezende, Carlos A.M., Le Hyaric, Mireille, Couri, Mara R.C., Simões, Cláudia M.O., de Almeida, Mauro V.
Format: Article
Language:English
Subjects:
Anti-HSV-1 activity
Antioxidant activity
Caffeic acid
Gallic acid
Quinic acid
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Summary:Nine caffeic and gallic acids derivatives were synthesized and evaluated for their antioxidant activity using the DPPH radical scavenging activity assay and for their antiherpes activity against HSV-1. All compounds displayed higher antioxidant activities than α-tocopherol. The most active antioxidant was compound 8 (IC50=177μM). Five compounds (7, 10, 11, 12 and 14) were found to possess anti-HSV-1 activity with selectivity indices values ranging from 7.0 to 27.1. The most active was compound 10 (IC50=15.2μM; SI=27.1).
ISSN:2210-5239
2210-5239
DOI:10.1016/j.bionut.2013.09.007