Synthetic routes to nanoconjugates of anthracyclines

[Display omitted] Anthracyclines (Anth) are widely used in the treatment of various types of cancer. Unfortunately, they exhibit serious adverse effects, such as hematopoietic depression and cardiotoxicity, leading to heart failure. In this review, we focus on recently developed conjugates of anthra...

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Bibliographic Details
Published in:Bioorganic chemistry 2020-03, Vol.96, p.103617, Article 103617
Main Authors: Piorecka, Kinga, Smith, David, Kurjata, Jan, Stanczyk, Maciej, Stanczyk, Wlodzimierz A.
Format: Article
Language:English
Subjects:
Anthracyclines
Anthracyclines - chemical synthesis
Anthracyclines - chemistry
Anticancer agents
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Chemistry Techniques, Synthetic - methods
Covalent linkers
Drug Design
Humans
Nanoconjugates
Nanoconjugates - chemistry
Nanotechnology - methods
Neoplasms - drug therapy
Prodrugs - chemical synthesis
Prodrugs - chemistry
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Summary:[Display omitted] Anthracyclines (Anth) are widely used in the treatment of various types of cancer. Unfortunately, they exhibit serious adverse effects, such as hematopoietic depression and cardiotoxicity, leading to heart failure. In this review, we focus on recently developed conjugates of anthracyclines with a range of nanocarriers, such as polymers, peptides, DNA or inorganic systems. Manipulation of the composition, size and shape of chemical entities at the nanometer scale makes possible the design and development of a range of prodrugs. In this review we concentrate on synthetic chemistry in the long process leading to the introduction of novel therapeutic products.
ISSN:0045-2068
1090-2120
DOI:10.1016/j.bioorg.2020.103617