Fluctuations of epigenetic regulations in human gastric Adenocarcinoma: How does it affect?

• Published in: Biomedicine & pharmacotherapy 2019-01, Vol.109, p.144-156
• Main Authors: Samadani, Ali Akbar, Noroollahi, Seyedeh Elham, Mansour-Ghanaei, Fariborz, Rashidy-Pour, Ali, Joukar, Farahnaz, Bandegi, Ahmad Reza
• Format: Article
• Language: English
• Subjects: Carcinogenesis; Epigenetic; Gastric cancer; Molecular signaling mechanisms
• ISSN: 0753-3322; 1950-6007
• DOI: 10.1016/j.biopha.2018.10.094

[Display omitted] •Aberrant DNA methylation mechanism in the promoter regions of certain genes, is the most important epigenetic hallmark in human GC especially as a target for detection and diagnosis in cancer treatment.•Hyper-methylation of tumor suppressor genes can also cause cancer, and these happenings are most in parts of the CpG.•It is possible for each of the related genes in different signaling pathways to have a limited role, but their silencing or down regulation at the same time, have an increasing role in the development of malignancies and eventually all of them can provide the susceptibility for cancer progression.•Epigenetic events are mediated by several molecular mechanisms including small non-coding RNAs, poly-comb protein complexes, histone modifications, and DNA methylation which the last category is the most important epigenetic factor.•Epigenetic mechanisms transmit genomic compatibility and adaption to an environment finally helping towards given different phenotype. Gastric cancer (GC) or human gastric adenocarcinoma is one of the most commonplace type of serious cancers and also the most common cause of cancer-related mortality in the world. Relatively, many studies have acknowledged that GC is a multi-factorial pathological situation that environmental factors, particularly dietary ones and H.pylori infection are considered to have a strong key role in the etiology of GC. Inappropriate dietary habits are the first cause as they affect main molecular functions related with the onset of the GC tumorigenesis and carcinogenesis. Correspondingly, cancer investigation has impressively zoomed on the different genetic markers and also molecular mechanisms pathways responsible for the progression of the GC. Various molecular signaling pathways such as WNT, NOTCH, SHH, MYC have different functions and analyzing their role in the GC is of great importance particularly for the treatment modalities. Proportionately, fluctuations of epigenetic alterations including DNA methylation, histone modification, histone acetylation and also histone phosphorylation’s are involved in all cancers specially the GC. Conspicuously, novel developments in cancer epigenetic have indicated immense reprogramming of every structure of the epigenetic mechanism in cancer, comprising microRNAs, nucleosome positioning, DNA methylation, noncoding RNAs, and histone modifications. In this account, aberrant DNA methylation mechanism in the promoter regions of certain gen