A comprehensive review on Pueraria: Insights on its chemistry and medicinal value

[Display omitted] •Pueraria is being used in food, cosmetic, and pharmaceutical industries.•Bioactivities of Pueraria are mainly due to isoflavones.•Puerarin is a marker compound of the Pueraria genus.•Puerarin received an investigational drug status for the treatment of alcohol abuse.•Pueraria has...

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Bibliographic Details
Published in:Biomedicine & pharmacotherapy 2020-11, Vol.131, p.110734, Article 110734
Main Authors: Wang, Shengguang, Zhang, Shiming, Wang, Shaoping, Gao, Peng, Dai, Long
Format: Article
Language:English
Subjects:
Alcohol abuse
Alcoholism - drug therapy
Animals
Antioxidants - pharmacology
Chemical and Drug Induced Liver Injury - prevention & control
Diabetes Mellitus - drug therapy
Humans
Isoflavones
Kudzu
Neoplasms - drug therapy
Neuroprotective Agents - pharmacology
Osteoporosis - drug therapy
Phytoestrogens
Phytotherapy
Plant Extracts - pharmacokinetics
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Postmenopause
Pueraria
Pueraria - chemistry
Puerarin
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Summary:[Display omitted] •Pueraria is being used in food, cosmetic, and pharmaceutical industries.•Bioactivities of Pueraria are mainly due to isoflavones.•Puerarin is a marker compound of the Pueraria genus.•Puerarin received an investigational drug status for the treatment of alcohol abuse.•Pueraria has beneficial effects in postmenopausal women & CHD patients. Pueraria species are listed in the Chinese Pharmacopeia and are being used for the treatment of various health ailments and in protecting health. Puerarin, a chemotaxonomic marker of Pueraria, received investigational drug status for the treatment of alcohol abuse and listed in DRUGBANK database. The purpose of this review is to provide insights on health benefits of Pueraria, its bioactive constituents and molecular mechanisms. The information is retrieved from various databases. The most investigated plant part is tuber and the major bioactive constituents are isoflavones. The Pueraria is reported to possess a lots of health benefits on brain, liver, heart, kidney, bone, stomach, muscle, skin, and reproductive system. Pueraria also shown beneficial effects in postmenopausal women. In this review, the scientific information on Pueraria reported until May 2020 were analysed and summarized logically to appreciate its health benefits and to identify research gaps.
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2020.110734