The impact of chicory (Cichoriumintybus L.) on hemodynamic functions and oxidative stress in cardiac toxicity induced by lead oxide nanoparticles in male rats

• Published in: Biomedicine & pharmacotherapy 2021-05, Vol.137, p.111324, Article 111324
• Main Authors: Elgharabawy, Rehab M., Alhowail, Ahmad H., Emara, Ashraf M., Aldubayan, Maha A., Ahmed, Amira S.
• Format: Article
• Language: English
• Subjects: Animals; Biomarkers; Cardiac functions; Cardiotoxicity; Chicory (Cichoriumintybus L.); Cichorium intybus - chemistry; Free Radical Scavengers - therapeutic use; Heart Function Tests; Hemodynamics - drug effects; Lead; Lead oxide nanoparticle; Lead Poisoning - drug therapy; Lead Poisoning - pathology; Male; Myocardium - pathology; Nanoparticles; Oxidative stress; Oxidative Stress - drug effects; Oxides - poisoning; Phytotherapy; Plant Extracts - chemistry; Plant Extracts - therapeutic use; Rats
• ISSN: 0753-3322; 1950-6007
• DOI: 10.1016/j.biopha.2021.111324

[Display omitted] •Lead oxide nanoparticles (PbO NPs) were associated with cardiac toxicity.•PbO NPs induced oxidative stress and histological structure.•Chicory modulates cardiac indices and oxidative stress changes induced by PbO NPs. A common environmental pollutant, lead can induce toxicity in several organ systems. A range of industrial and/or household materials and products contain lead, and food/liquid ingestion and inhalation are the mechanisms through which lead is introduced into the human body. Since knowledge about the cardiac toxicity of acute lead nanoparticles is limited, this work sought to shed more light on the issue by investigating the therapeutic effects of chicory extract based on rat models to elevate cardiac functions and oxidative stress. Four research groups were used, each consisting of ten albino rats of male sex and adult age. The groups were: control group, chicory group, lead oxide nanoparticle group, and lead oxide nanoparticle + chicory group. Compared to the control and chicory groups, the lead oxide nanoparticle group displayed a notable increase in heart functions and oxidative stress markers as well as alterations in cardiac histological structure. On the other hand, cardiac function modifications were counteracted through four-week administration of lead oxide nanoparticles alongside chicory. Heart damage caused by lead oxide nanoparticles may be attenuated by chicory through scavenging of free radicals.