Rigid nanoparticle-based delivery of anti-cancer siRNA: Challenges and opportunities

Gene therapy is a promising strategy to treat various genetic and acquired diseases. Small interfering RNA (siRNA) is a revolutionary tool for gene therapy and the analysis of gene function. However, the development of a safe, efficient, and targetable non-viral siRNA delivery system remains a major...

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Bibliographic Details
Published in:Biotechnology advances 2014-07, Vol.32 (4), p.831-843
Main Authors: Wang, Zhiyong, Liu, Gang, Zheng, Hairong, Chen, Xiaoyuan
Format: Article
Language:English
Subjects:
Antineoplastic Agents - administration & dosage
Biological and medical sciences
Biomarkers - metabolism
Biotechnology
Calcium Phosphates - chemistry
Cell Membrane - metabolism
Ferric Compounds - chemistry
Fundamental and applied biological sciences. Psychology
Gene delivery
Gene Silencing
Gene therapy
Gene Transfer Techniques
Genetic Therapy - methods
Gold - chemistry
Humans
Immunity, Innate
Ligands
Nanoparticles
Nanoparticles - chemistry
Nanotechnology - methods
Nanotubes, Carbon - chemistry
Neoplasms - therapy
Quantum Dots
RNA Interference
RNA interference (RNAi)
RNA, Small Interfering - administration & dosage
RNA, Small Interfering - metabolism
Silicon Dioxide - chemistry
Small-interfering RNA (siRNA)
Surface Properties
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Summary:Gene therapy is a promising strategy to treat various genetic and acquired diseases. Small interfering RNA (siRNA) is a revolutionary tool for gene therapy and the analysis of gene function. However, the development of a safe, efficient, and targetable non-viral siRNA delivery system remains a major challenge in gene therapy. An ideal delivery system should be able to encapsulate and protect the siRNA cargo from serum proteins, exhibit target tissue and cell specificity, penetrate the cell membrane, and release its cargo in the desired intracellular compartment. Nanomedicine has the potential to deal with these challenges faced by siRNA delivery. The unique characteristics of rigid nanoparticles mostly inorganic nanoparticles and allotropes of carbon nanomaterials, including high surface area, facile surface modification, controllable size, and excellent magnetic/optical/electrical properties, make them promising candidates for targeted siRNA delivery. In this review, recent progresses on rigid nanoparticle-based siRNA delivery systems will be summarized. [Display omitted]
ISSN:0734-9750
1873-1899
DOI:10.1016/j.biotechadv.2013.08.020