Tenosynovial giant cell tumours of the hand: A multicentre case-control study

• Published in: Journal of plastic, reconstructive & aesthetic surgery reconstructive & aesthetic surgery, 2019-06, Vol.72 (6), p.918-923
• Main Authors: Linney, L.S., Al-Hassani, F., Pikturnaite, J., Mathew, B., Thornton, D., Wade, R.G., Pinder, R.M.
• Format: Article
• Language: English
• Subjects: Adult; Age Factors; Case-Control Studies; Dissection - adverse effects; Dissection - methods; Female; GCTTS; Giant Cell Tumor of Tendon Sheath - pathology; Giant Cell Tumor of Tendon Sheath - surgery; Giant cell tumours; Humans; Male; Middle Aged; Mitotic Index - methods; Neoplasm Recurrence, Local - diagnosis; Neoplasm Recurrence, Local - epidemiology; Outcome Assessment, Health Care; Radiotherapy - adverse effects; Radiotherapy - methods; Retrospective Studies; Risk Assessment - methods; Sex Factors; TSGCT; Tumours of the hand
• ISSN: 1748-6815; 1878-0539
• DOI: 10.1016/j.bjps.2019.01.021

Many factors have been proposed to contribute to the risk of recurrent tenosynovial giant cell tumours (TSGCT); however, we remain unable to predict those at risk, which formed the rationale for this multicentre retrospective case-control study of 28 patients with recurrence. We included cases of recurrence in a 1:1 ratio matched for age and sex with controls over 10 years. Using Cox regression, we present hazard ratios (HRs) for recurrence with 95% confidence intervals (CIs). Out of 285 cases, 28 individuals developed recurrence after a median of 2.4 years. Recurrent TSGCT had a higher mitotic count/mm2 in the primary tumour (median increase of 3 [IQR 1, 7]). Mitotic count in the primary tumour was associated with the risk of recurrence (adjusted HR 1.1 [95% CI 1.1, 1.2]) meaning that for every additional mitosis, the risk of recurrence increased by 10% per annum. We recommend a prospective cohort study to validate our findings.