Inhibition of the metastatic progression of breast and colorectal cancer in vitro and in vivo in murine model by the oxidovanadium(IV) complex with luteolin

• Published in: Bioorganic & medicinal chemistry 2016-11, Vol.24 (22), p.6004-6011
• Main Authors: Naso, Luciana G, Badiola, Iker, Marquez Clavijo, Joana, Valcarcel, María, Salado, Clarisa, Ferrer, Evelina G, Williams, Patricia A M
• Format: Article
• Language: English
• Subjects: Animals; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Breast Neoplasms - drug therapy; Breast Neoplasms - pathology; Cell Movement - drug effects; Cell Proliferation - drug effects; Colorectal Neoplasms - drug therapy; Colorectal Neoplasms - pathology; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Liver Neoplasms, Experimental - drug therapy; Liver Neoplasms, Experimental - pathology; Luteolin - chemistry; Luteolin - pharmacology; Mice; Mice, Inbred BALB C; Molecular Structure; Structure-Activity Relationship; Tumor Cells, Cultured; Vanadium - chemistry; Vanadium - pharmacology
• ISSN: 0968-0896; 1464-3391
• DOI: 10.1016/j.bmc.2016.09.058

The anticancer and antimetastatic behavior of the flavonoid luteolin and its oxidovanadium(IV) complex [VO(lut)(H O) ]Na·3H O (VOlut) has been investigated. Considering that the complex displayed strong anticancer activity on MDAMB231 human breast cancer cell line we herein determined through in vitro assays that the complex would probably reduce breast cancer cell metastasis in a higher extent than the natural antioxidant. In the CT26 colon cancer cell line a stronger anticancer effect has also been determined for the complex (IC 0.9μM) and in addition it did not exert toxic effects on normal colon epithelial cells at concentrations up to 10μM. Working with a murine model of highly aggressive, orthotopic colon cancer model (CT26 cancer cell lines) it has been determined that the complex might prevent metastatic dissemination of the colon cancer cells to the liver. The flavonoid luteolin also exerted anticancer effects (at a low degree, IC 5.9μM) on CT26 cell line and produced a 24% reduction of colon cancer liver metastasis.