Identification of purine inhibitors of phosphodiesterase 7 (PDE7)

A series of purine based inhibitors of PDE7 has been derived from screening lead 1a. The synthesis, structure–activity relationships (SAR), and selectivity against several other PDE family members are described. A series of purine based inhibitors of PDE7 has been derived from screening lead 1a. The...

Full description

Saved in:
Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2004-06, Vol.14 (11), p.2955-2958
Main Authors: Pitts, William J., Vaccaro, Wayne, Huynh, Tram, Leftheris, Katerina, Roberge, Jacques Y., Barbosa, Joseph, Guo, Junqing, Brown, Baerbel, Watson, Andrew, Donaldson, Karen, Starling, Gary C., Kiener, Peter A., Poss, Michael A., Dodd, John H., Barrish, Joel C.
Format: Article
Language:English
Subjects:
3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors
Binding Sites
Biological and medical sciences
Cell Line
Cyclic Nucleotide Phosphodiesterases, Type 7
Enzyme Inhibitors - chemical synthesis
Enzyme Inhibitors - pharmacology
Humans
Inhibitor
Inhibitory Concentration 50
Ligands
Medical sciences
Miscellaneous
PDE7
Pharmacology. Drug treatments
Phosphodiesterase 7
Purines - chemical synthesis
Purines - pharmacology
Structure-Activity Relationship
T-Lymphocytes - enzymology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A series of purine based inhibitors of PDE7 has been derived from screening lead 1a. The synthesis, structure–activity relationships (SAR), and selectivity against several other PDE family members are described. A series of purine based inhibitors of PDE7 has been derived from screening lead 1a. The synthesis, structure–activity relationships (SAR), and selectivity against several other PDE family members are described.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2004.03.021