Design and synthesis of a potent macrocyclic 1,6-napthyridine anti-human cytomegalovirus (HCMV) inhibitors

A novel class of macrocyclic 1,6-napthyridines designed to adopt the presumed bioactive conformation of anti-HCMV acyclic 1,6-napthyridines are described. Both 14- and 15-membered macrocycles were shown to be highly potent against HCMV HSV-1 and HSV-2. A novel class of macrocyclic 1,6-napthyridines...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2005-03, Vol.15 (6), p.1693-1695
Main Authors: Falardeau, Guy, Lachance, Hugo, St-Pierre, Annie, Yannopoulos, Constantin G., Drouin, Marc, Bédard, Jean, Chan, Laval
Format: Article
Language:English
Subjects:
Anti-proliferative agents
Anti-virals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antineoplastic agents
Antiviral agents
Biological and medical sciences
General aspects
HCMV
HSV
Macrocycle
Medical sciences
Naphthyridine
Pharmacology. Drug treatments
Polycyclic heterocyclic compounds
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Summary:A novel class of macrocyclic 1,6-napthyridines designed to adopt the presumed bioactive conformation of anti-HCMV acyclic 1,6-napthyridines are described. Both 14- and 15-membered macrocycles were shown to be highly potent against HCMV HSV-1 and HSV-2. A novel class of macrocyclic 1,6-napthyridines designed to adopt the presumed bioactive conformation of anti-HCMV acyclic 1,6-napthyridines are described. Both 14- and 15-membered macrocycles were shown to be highly potent against HCMV HSV-1 and HSV-2.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2005.01.050