Aqua mediated synthesis of substituted 2-amino-4H-chromenes and in vitro study as antibacterial agents

A simple, clean, environmentally benign route to the synthesis of 2-amino-chromenes is described using K2CO3 as a green catalyst in water under microwave irradiation. This implies a convenient route avoiding the usage of hazardous organic solvents and organic bases. This technique requires only wate...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2005-10, Vol.15 (19), p.4295-4298
Main Authors: KIDWAI, Mazaahir, SAXENA, Shilpi, KHALILUR RAHMAN KHAN, M, THUKRAL, Sharanjit S
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Benzopyrans - chemical synthesis
Benzopyrans - pharmacology
Biological and medical sciences
Carbonates
Environmental Pollution - prevention & control
Escherichia coli - drug effects
Medical sciences
Microwaves
Pharmacology. Drug treatments
Potassium
Pseudomonas aeruginosa - drug effects
Solutions
Spectrum Analysis
Staphylococcus aureus - drug effects
Structure-Activity Relationship
Water
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Summary:A simple, clean, environmentally benign route to the synthesis of 2-amino-chromenes is described using K2CO3 as a green catalyst in water under microwave irradiation. This implies a convenient route avoiding the usage of hazardous organic solvents and organic bases. This technique requires only water in both the reaction step and workup, thus rendering the whole procedure into a truly ecofriendly green protocol. All the synthesized compounds were shown to possess antibacterial activity as tested in vitro against standard strains of Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2005.06.041