Novel inhibitors of the hepatitis C virus NS3 proteinase

The hepatitis C virus proteinase inhibitor 4-methyl-1-(phenylmethyl)-2,6-pyridinedione 1 undergoes a novel autoxidation process, on silica gel, leading to the dimer 2 as the major product, a relatively more potent inhibitor of the enzyme.

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2005-10, Vol.15 (19), p.4275-4278
Main Authors: Bennett, Frank, Liu, Yi-Tsung, Saksena, Anil K., Arasappan, Ashok, Butkiewicz, Nancy, Dasmahapatra, Bimalendu, Pichardo, John S., Njoroge, F. George, Patel, Naginbhai M., Huang, Yuhua, Yang, Xiaozheng
Format: Article
Language:English
Subjects:
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Antiviral Agents - chemical synthesis
Antiviral Agents - pharmacology
Biological and medical sciences
Dimerization
Hepatitis
Hepatitis C - enzymology
Inhibitory Concentration 50
Medical sciences
Oxidation-Reduction
Pharmacology. Drug treatments
Proteinase
Pyridines - chemistry
Serine Proteinase Inhibitors - chemical synthesis
Serine Proteinase Inhibitors - pharmacology
Structure-Activity Relationship
Viral Nonstructural Proteins - antagonists & inhibitors
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Description
Summary:The hepatitis C virus proteinase inhibitor 4-methyl-1-(phenylmethyl)-2,6-pyridinedione 1 undergoes a novel autoxidation process, on silica gel, leading to the dimer 2 as the major product, a relatively more potent inhibitor of the enzyme.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2005.06.079