Synthesis and antitubercular activity of quaternized promazine and promethazine derivatives

Quaternized promazine derivatives 4b (R 1 = CF 3, R 2 = 4-Cl; X = Cl) and 4c (R 1 = CF 3; R 2 = 3-Cl; X = Cl) inhibit actively growing and non-replicating Mycobacterium tuberculosis at

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2007-03, Vol.17 (5), p.1346-1348
Main Authors: Bate, Aaron B., Kalin, Jay H., Fooksman, Eric M., Amorose, Erica L., Price, Cristofer M., Williams, Heather M., Rodig, Michael J., Mitchell, Miguel O., Cho, Sang Hyun, Wang, Yuehong, Franzblau, Scott G.
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antitubercular
Antitubercular Agents - chemical synthesis
Antitubercular Agents - pharmacology
Biological and medical sciences
Chlorpromazine
Chlorpromazine - chemical synthesis
Chlorpromazine - pharmacology
Medical sciences
Mycobacterium tuberculosis - drug effects
Pharmacology. Drug treatments
Promazine
Promazine - chemical synthesis
Promazine - pharmacology
Promethazine
Promethazine - chemical synthesis
Promethazine - pharmacology
Quaternary Ammonium Compounds - chemical synthesis
Quaternary Ammonium Compounds - pharmacology
Quaternized
Structure-Activity Relationship
Triflupromazine
Triflupromazine - chemical synthesis
Triflupromazine - pharmacology
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Summary:Quaternized promazine derivatives 4b (R 1 = CF 3, R 2 = 4-Cl; X = Cl) and 4c (R 1 = CF 3; R 2 = 3-Cl; X = Cl) inhibit actively growing and non-replicating Mycobacterium tuberculosis at
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2006.11.091