Discovery of novel small molecule cell type-specific enhancers of NF-κB nuclear translocation

A reported IKKβ inhibitor to inhibit NF-κB transcriptional activities in Jurkat T cells was found to enhance NF-κB translocation in HUVEC cells. These studies suggested a noncanonical NF-κB signaling independent to IKKβ in HUVEC cells. An IKKβ inhibitor reported to block NF-κB transcriptional activi...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2009-02, Vol.19 (4), p.1191-1194
Main Authors: Gong, Gangli, Xie, Yuli, Liu, Yidong, Rinderspacher, Alison, Deng, Shi-Xian, Feng, Yan, Zhu, Zhengxiang, Tang, Yufei, Wyler, Michael, Aulner, Nathalie, Toebben, Udo, Smith, Deborah H., Branden, Lars, Chung, Caty, Schürer, Stephan, Vidović, Dušica, Landry, Donald W.
Format: Article
Language:English
Subjects:
Activator
HUVEC cells
NF-κB
Quinazoline
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Summary:A reported IKKβ inhibitor to inhibit NF-κB transcriptional activities in Jurkat T cells was found to enhance NF-κB translocation in HUVEC cells. These studies suggested a noncanonical NF-κB signaling independent to IKKβ in HUVEC cells. An IKKβ inhibitor reported to block NF-κB transcriptional activities in Jurkat T cells, was found to enhance NF-κB translocation in HUVEC cells. These studies suggested a noncanonical NF-κB signaling pathway independent of IKKβ in HUVEC cells.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2008.12.086