Synthesis and antitumor activity of daunorubicin conjugates with of 3,4-methylendioxybenzaldehyde

[Display omitted] The design of hybrid (chimeric) molecules containing two different pharmacophores connected via a spacer (linker) is a promising approach to the functionalization of natural compounds and potentially of drug molecules. These are important examples for the use of this approach with...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2019-10, Vol.29 (19), p.126617, Article 126617
Main Authors: Moiseeva, Aleksandra A., Artyushin, Oleg I., Anikina, Lada V., Brel, Valery K.
Format: Article
Language:English
Subjects:
Anthracycline antibiotics
Anticancer activity
Antitumor conjugates
Daunorubicin
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Summary:[Display omitted] The design of hybrid (chimeric) molecules containing two different pharmacophores connected via a spacer (linker) is a promising approach to the functionalization of natural compounds and potentially of drug molecules. These are important examples for the use of this approach with anthracycline antibiotics. The use of this methodology may help to eliminate some of the drawbacks of anthracycline drugs, e.g., high cardiotoxicity and MDR development.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2019.08.021